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Case Study: Modernizing Clinical Trial Forecasting on Databricks | 12x Cost Optimization

Case Studies

Re-Architecting Clinical Enrolment Forecasting on Databricks: 12x Platform Cost Optimization  

At a Glance

Industry:  Biopharmaceutical Services 
Location: United States (Global Ops)
Client:  Leading Global Clinical Research Organization 

A global biopharmaceutical services organization operating multi-study clinical programs relies on enrolment forecasting to manage execution timelines and mitigate delivery risk. Forecast accuracy and refresh reliability directly impact study governance and operational planning. As study volume increased, the existing ingestion and transformation framework within the SNAP analytics environment struggled to scale efficiently.  

The organization engaged KPI Partners to modernize its Forecast Data Product within its SNAP analytics platform. KPI redesigned the legacy ingestion and transformation framework using Databricks to improve reliability, enhance scalability, and reduce platform costs while strengthening trust in clinical reporting. 

 

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Technology

  • Azure Databricks
  • XGBoost
  • spark
  • Microsoft_Azure_KPI Partners
  • ml_flow
  • Microsoft Power BI
  • Databricks Unity Catalog-1
  • KPI_Accelerators_logo-1

The Challenge

 

Compute-Heavy Full Loads

ADF full-load pipelines ran for nearly 10 hours, and incremental loads ran for about 45 minutes, driving high Azure resource consumption and increasing platform costs.

 

Pipeline Fragmentation

The team managed six separate ADF pipelines for full and incremental processing, increasing orchestration complexity and maintenance overhead.

 

Hard Delete Reconciliation

The team executed weekly full reloads to address source-side hard deletes, adding unnecessary processing time.

 

Reporting Discrepancies

Business reports diverged from source data until the team ran a full load to realign datasets.

 

Workflow Timeouts

Long-running full loads frequently timed out, forcing production support teams to monitor pipelines continuously and intervene manually.

 

 

Scaling Clinical Analytics with Incremental-First Architecture | 12x Cost Optimization

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